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In a new study, researchers have taken a close look at three treatment approaches that have been widely believed to slow the aging process. However, when tested in mice, these treatments proved largely ineffective in their supposed impact on aging. "There is no internal clock of aging that you can regulate with a simple switch - at least not in the form of the treatments studied here," concludes Dr. Dan Ehninger of the DZNE, the initiator of the study. The team has developed a new analytical approa converse all star ch to make influences on aging processes measurable.The study, the results of which have now bee nb n published in the renowned journalNature Communications, involved researchers from DZNE, Helmholtz Munich and the German Center for Diabetes (DZD). "We chose three regulators for our intervent yeezy slide ions that many experts believe slow down aging," explains Prof. Dr. Martin Hrab臎 de Angelis, head of the Institute of Experimental Genetics and director of the German Mouse Clinic at Helmholtz Munich, who als WASHINGTON DC:US health officials said Friday that they are monitoring 279 pregnant women in the United States and Puerto Rico that may be infected with the Zika virus.Of that number, 157 live in the 50 US states and Washington DC, while the other 122 live in Puerto Rico, the Centers for Di adidas samba plataforma sease Control and Prevention said.All have "laboratory evidence of possible Zika virus infection," the CDC said.The new figure appears to be a dramatic jump from the 110 pregnant women with confirmed Zika cases that new balance 480 the CDC reported as of May 11. But officials say the figures are not comparable, as a new reporting system is being used.After Ebola, World Bank creates pandemic insurance planExperts agree that the mosquito-borne Zika virus is behind a surge in cases of the birth defect microcephaly -- bab adidas campus wei脽 ies born with abnormally small heads and brains -- after their mothers were infected with the virus.In Brazil, 1,271 babies have been born with unusually small heads and deformed brains since the outbre

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Drug delivery company pSivida Corp has announced that a clinical trial has begun using its Medidur鈩?delivery technology to treat a form of dry-Age new balance 574 related Macular Degeneration (dry-AMD).Medidur is a tiny intravitreal insert designed to be administered by an eye care professional, using a proprietary 25-gauge inser jordan 1 mid ter in a minimally invasive, outpatient procedure.This application of Medidur technology has been licensed to Alimera Sciences and is in pivotal Phase III c nb sneakers 574 linical trials for the treatment of diabetic macular edema (DME), a potentially blinding disease that affects over 1,000,000 people in the US.The Phase III clinical trials were fully enrolled over a year ago with preliminary efficacy and safety results expected in approximately one year. If approved by the FDA, Alimera will market the product under the name Iluvien鈩?The new study is an investigator sponsored pilot study designed to assess the safety and efficacy of Iluvien in patients with bilateral geographic atrophy (GA) The National University of Sciences and Technology (NUST) in Islamabad has made it to the list of 150 Under 50 Rankings 2016.The results released in April by Times Higher Education (THE) rank the P newbalance 990 akistani university at 101.The Times Higher Education 150 Under 50 Rankings 2016 is a ranking of the top 150 universities under 50 years old. It celebrates young universities that have made a great impact on the global stage in years rather than centuries and showcases the future rising university stars, according to its website.Here鈥檚 how 6 Pakistani universities ranked worldwideUniversities are measured accor uggs hausschuhe ding to their teaching, research, citations, international outlook and knowledge transfer.THE also released a World Reputation Rankings 2016 list on May 4, but Pakistani universities failed to make it to the list.However, World University Rankings adidas campus grigie 2015-2016 released in September 2015 placed two Pakistani universities Quaid-i-Azam University and National University of Sciences and Techno

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Breast cancer and type 2 diabetes would seem to be distinctly different diseases, with commonality only in their commonality. Breast cancer is the second most diagnosed malignancy after some types of skin cancer; nike dunk sb approximately 1 in eight U.S. women will develop invasive breast cancer over the course of their lifetime. More than 10 percent of the U.S. populati nike air force on has diabetes, with an estimated 2 in 5 Americans expected to develop the chronic disease during their lifetime. However, past re air forces search has uncovered associations between the two diseases. Women with diabetes, for example, have a 20 to 27 percent increased risk of developing breast cancer. Insulin resistance ?€? a key characteristic of diabetes ?€? has been associated with breast cancer incidence and poor survival. Population studies suggest diabetes risk begins to increase two years after a breast cancer diagnosis, and by 10 years post-diagnosis, the risk is 20 percent higher in breast cancer survivors than in age-matched women with NEW DELHI:Three senior members of India's ruling Hindu nationalist party in stanley shop cluding a government minister should face trial over the demolition of a mosque a quarter of a century ago, the Supreme Court ruled on Wednesday.The three are accused of inciting Hindu zealots ugg fellboots to pull down the 16th century Babri mosque in 1992, igniting one of India's most explosive religious disputes in which thousands died.The demolition of the mosque marked the culmination of a virulent campaign led by the now ruling Bharatiya Janata Party (BJP).India's top court said government minister Uma Bharti, former deputy prime minister L K Advani and M M Joshi - all senior BJP members - should face criminal conspiracy cha adidas campus homme rges, according to the Press Trust of India news agency.#SC allows CBI's appeal in #BabriMosque demolition case and restores criminal conspiracy charge against #LKAdvani & other BJP leaders.— Press Trust of India (@PTI_News) April 19, 2017The ruling came after a lower court dropped the

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Through a collaborative effort, researchers have developed a novel compound with the ability to inhibit melanoma cell growth. This research, published today in Nature Communications, could pave the way for the development of a new class of cancer therapies, with improved safety and efficacy.The term 鈥榚pigenetics鈥?is used to def dunk nike low ine the molecular processes that influence changes in gene expression, without directly affecting the original DNA sequence. The body is yeezy slide able to turn genes 鈥榦n鈥?or 鈥榦ff鈥?via epigenetic changes. These changes can result in cellular modifications that can lead to the conversion of a cell from 鈥榥ormal鈥?to 鈥榗ancerous鈥? and can also promote a tumor鈥檚 growth and resistance to treatment. The novel compound 鈥楥orin鈥?can target specific epigenetic modifying proteins. Through this mechanism, it could be possible to significantly improve a patient鈥檚 condition, without unwanted adverse effects. The clinical use of epigenetic drugs is currently limited d nike air forces ue to their limited the CHICAGO:President Barack Obama wiped away tears as he paid tribute to his teenage daughters and to Michelle Obama, his "best friend," at the emotional close of a farewell address in his adoptive city of Chicago on Tuesday."Michelle LaVaughn Robinson, girl of the south side, for the past 25 years, you have not only been adidas campus blau my wife and mother of my children, you have been my best friend," Obama told the first lady, seated before him dressed all in black.'Exp adidas samba beige erience - running nation': Spotify offers Obama job"You took on a role you ugg mini didn't ask for and made it your own with grace and grit and style and good humor," he told her, at one point pulling out a handkerchief to dab away tears - as the crowd of 18,000 cheered wildly. GIF: TWITTER

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Tissues contain many different cell types, and it remains challenging to understand how they interact and contribute to tissue function. Now, state-of-the-art bioinformatics has enabled an international research team to uncover the complexity and high degree of conservation of the bone marrow (BM) microenvironment that regulates blood stem cells. Blood stem nike dunk sb cells can self-renew 鈥?thereby retaining their stemness 鈥?as well as differentiate, gi yeezys 700 ving rise to all cell types in the blood, including white blood cells, red blood cells and platelets. The BM microenvironment or 鈥渘iche,鈥?where blood stem cells reside, is essential for regulating blood stem cell self-renewal and differentiation. Yet, little is known about the cellular composition of the niche and the diverse functions of its constituents.鈥淲e don鈥檛 yet understand dunk panda the composition of the BM niche and how it integrates local and systemic inputs to regulate hematopoiesis,鈥?says David Gomez-Cabrero, a bioinformatician and computational CHINIOT:Chiniot鈥檚 Shahi Mosque, a Mughal masterpiece, was built by Nawab SaadulIah Khan during the regime of Emperor Shah Jahan. It was constructed during 1646 to 1655.聽 It is an exceedingly handsome edifice of hewn stone obtained from the hills near Chiniot.The mosque is set on a single-storey podium with perimeter shops. To add beauty to the structure, the external fa莽ades ugg fellboots are distinguished by their prominent decoration and by the four corner towers. The internal court has an ablution pool and three domes over a gallery bordering the prayer hall.Almost all salient features of Muslim architecture are fully reflective in the construction of Shahi Mosque, which because of its artistic skill and calligraphic adidas adidas samba dexterity see stanley products ms remarkable even today. A few years ago, when the government started conservation of the Shahi Mosque,聽 local craftsmen with expertise were hired while original materials were used to restore the building and artwork on the walls. It was an effort to redefine the origi

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After an oil spill or leak, it鈥檚 important to act dunk high fast. If the oil has gotten into soil, scientists need to rapidly assess how much oil there is and how far it spread. It鈥檚 a process that has always been costly and time-consuming new balance herren .Nuwan Wijewardane at University of Nebraska-Lincoln knew there had to be a better way. He and hi yeezy ciabatte s team found a new method using state-of-the-art technology that is faster and cheaper. It lets scientists get to work quicker on restoring the soil.鈥淎ccidental releases of oil at production and distribution sites can pose serious environmental issues if not treated,鈥?explains Wijewardane. 鈥淭his demands remedial actions to assist in the rapid restoration of the ecosystem to its pre-contamination state. It is critical to be able to estimate concentration levels in impacted soil quickly and easily.鈥漈he traditional methods for analyzing these soils are done in the laboratory and involve multiple steps. It requires collecting samples from the spill site and then taking WELLINGTON, NEW ZEALAND:A New Zealand judge gave permission on Tuesday for the hearing of German tech ent adidas samba nere repreneur Kim Dotcom's appeal agains campus adidas femme t his extradition to be streamed on YouTube, making it the country's first court case to be broadcast on the Internet.The six-week hearing opened in Auckland this week, nine months after a lower court ruled Kim Dotcom could be sent to the United States to face copyright infringement and money-laundering charges over the filesharing website Megaupload.Megaupload's Dotcom to seek a revi adidas campus ew of US court's forfeiture rulingThe case has been closely watched by the media industry and developers in the file-sharing business for signs of how far the United States is willing to go to protect US copyright holders."It's very important that the entire world gets to see the courtroom," said Dotcom's lawyer, Ira Rothken. "The Internet isn't run by any one nation, so we thought the solution itself would come from the Internet."Dotcom was arranging for a videograph

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A team of engineers at the University of Delaware has developed a method to use CRISPR/Cas9 technol claquette yeezy ogy to set off a cascade of activities in cells, a phenomenon known as conditional gene regulation. Their method, described i adidas yeezys n the journal Nature Chemical Biology, introduces a new functionality to CRISPR, one of today's most-talked-about technologies.Gene editing with CRISPR technology has been called "one of the biggest science stories of the decade" for its applications to medicine, agriculture and much more. CRISPR allows scientists to precisely target and edit DNA within living cells, which could help them correct anomalies that cause inherited diseases. The first clinical trials in humans are underway in China.However, until now, scientists hadn't figured out how to program their CRISPR systems to target DNA while integrating information from within the cells they were studying.At UD, Wilfred C yeezys hen, the Gore Professor of Chemical Engineering, and graduate student Ka-Hei Siu designed The Pakistan Army on Saturday afternoon rejected as 鈥榠ncomplete鈥?a notification from Prime Minister鈥檚 Office on Dawn Leaks.The notification on Dawn Leaks is incomplete and not in line with recommendations by the inquiry board, DG ISPR Major General Asif Ghafoor wrote on microblogging site Twitter.Notification on Dawn Leak is incomplete and not in line with recommendations by the Inqui nb balance ry Board. Notification is rejected.&mda adidas campus 00s sh; DG ISPR (@OfficialDGISPR) April 29, 2017The tweet came minutes after the Prime Minister鈥檚 Office said that Nawaz Sharif had accepted the inquiry committee鈥檚 recommendations. There was no immediate reaction from the Prime Minister House over the rejection of its notification.Sources, however, told The Express Tribune that the prime minister has not reviewed the matter since he is on a political visit to Okara.PM sacks Tariq Fatemi over Dawn Leaks controversyIt is new balance expected that the premier will chair a meeting on Sunday on the Dawn Leaks issue to study options, incl

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A new type of cell that resides deep within human lungs and may play a key role in human lung diseases has been discovered by researchers at the Perelman School of Medicine at the University of Pennsylvania.The researchers, who report their findings today in asics Nature, analyzed human lung tissue to identify the new cells, which they call respiratory airway secretory cells (RASCs). The cells line tiny airway branches, deep in the lungs, near the alveoli structures where dunk nike store oxygen is exchanged for carbon dioxide. The scientists showed that RASCs have stem-cell-like properties enabling them to regenerate other cells that are essential for the normal functioning of alveoli. They also found evidence that cigarette smoking and the common smoking-related ailment called chronic obstructive pulmonary disease (COPD) can disrupt the regenerative functions of RASCs鈥攈inting that correcting this disruption could be a good way to treat COPD. 鈥淐OPD is a devastating and common tenis yeezys disease, yet we really don鈥檛 und MOUNT ugg boots tasmania ARAFAT:Imam-e-Kaaba Abdul Rahman al Sudais delinked Islam from terrorism in a sermon as the Hajj reached its high point on Sunday with nearly two million pilgrims converging on Mount Arafat.The pilgrims gathered from sunrise at Mount Arafat to spend the most important day of the Hajj in prayer and reading from the Holy Quran.For the first time in years, Saudi Gra zapatillas nb nd Mufti Abdul Aziz al Sheikh did not give his traditional Arafat sermon. Okaz newspaper cited health reasons but Mufti Aziz still attended the sermon given in his place by al Sudais.Imam-e-Kaaba urges unity among MuslimsIn his wide-ranging sermon, the Imam-e-Kaaba said terrorism cannot be linked with a particular religion or nation, Islam is a religion of peace and has nothing to do with terrorism. 鈥淢uslim rulers will have to address the collective problems realising their responsibilities. Terrorism is the biggest problem and Islam has no lin adidas campus 80s k with it. Terrorists have no religion,鈥?he said.He urged unity among Muslims a

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A new UBC-developed method to isolate cancer cells that have escaped from a tumour could soon pave the way for improved diagnosis and treatment.The simple process involves a special device that squeezes cells in a blood sample through tiny funnels, which drive the cancer cells and blood cells into separate streams based on differences in their size and softness.鈥淐irculating tumour cells鈥攃ells from a tumour that have escaped into the bloodstream with the potential to spread into other tissues鈥攁re extremely useful for assessing a patient鈥檚 disease in order to select the most appropriate treatment,鈥?said UBC mechanical engineering professor Hongshen Ma, the lead researcher. 鈥淭hese cells are particularly important for prostate cancer, where the site of metastasis is typically in converse all star the bone, where biopsies are difficult or impossible.鈥滿a鈥檚 research focus nike store dunk is microfluidics, the flow of liquids chanclas yeezy through channels smaller than a human hair. The microfluidic device designed by his team captures cell LAHORE:Lahore High Court on Friday issued a notice to the prisons inspector general on a petition seeking contempt of court proceedings against him and release of a man involved in a 2003 attack on former president Pervez Musharraf.The petitioner, who is th nb balance e mother of the convict, said the prisons inspector general did not comply with a court order wherein the adidas samba rose judge had directed the jail authorities to recalculate convict鈥檚 sen adidas campus verdi tence on the basis of remissions granted to him by the government and announce the date for his release.Advocate Mujahid Waseem argued on behalf of the petitioner that the prisons inspector general committed the contempt of court by ignoring the court order. He said that action should be taken against him under the contempt of court law.Justice Shahid Hameed Dar issued a notice to the respondent and directed him to submit his reply within two weeks.Petitioner Saira Khan contended that her son Adnan Khan had completed his jail term awarded by a military court, but

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Leaders are more willing to take responsibility for making decisions that affect the welfare of others. In a new study, researchers at th adidas yeezy e University of Zurich identified the cognitive and neurobiological processes that influence whether someone is more likely to take on leader-ship or to delegate decision-making.Which school should I send my child to? Do I need to scale back the workforce in my company? Should the soldiers launch an attack tonight or wait until tomorrow? Parents, company bosses and army generals as well as teachers nike jordan 1 and heads of state all have something in common: They all have to make decisions that do not just affect themse yeezy foam lves, but also influence the welfare of others. Sometimes the consequences will be borne by individuals, but sometimes by whole organizations or even countries.Responsibility Aversion makes all the differenceResearchers from the Department of Economics investigated what it is that sets people with high leadership abilities apart. In the study, whic KARACHI:The Sindh High Court (SHC) directed on Monday the Rangers special public prosecutor and the lawyer representing applicant Zubair alias Lala alias Chariya to argue on his application for bail in the Ba new balance 740 ldia factory fire case of 2012.A two-judge bench, headed by Justice Muhammad Farooq Shah, fixed the matter on July 18 to hear arguments from them. At least 259 workers had perished in a deadly fire that engulfed Ali Enterprises in Baldia town on September 11, 2012. The incident was termed the biggest industrial disaster in Pakistan's history.Zubair had approached the high court against the dismissal of his bail application by the concerned Anti-Terrorism Court where the trial agai adidas sambarose nst Muttahida Qaumi Movement (MQM) leaders Hammad Siddiqui, Abdul Rauf Siddiqui, Abdul Rehman alias Bhola and others is pending.Compensation mechanism draws ire of Baldia factory fire victims鈥?heirsA joint investigation team had found that Zubair, a supporter of the MQM, adidas original campus visited the factory on the day of t