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Results from a new clinical trial have identified pegozafermin as a promising treatment for liver damage (fibrosis) related to non-alcoholic steatohepatitis (NASH). The research is published in the New England Journal of Medicine.A potential new treatment for NASHNASH is a type of non-a nike air force 1 lcoholic f yeezy a nike dunk tty liver disease (NAFLD). Approximately 24% of U.S. adults have NAFLD, according to the National Institutes of Health, while 1.5鈥?.5% have NASH.NASH typically has very few symptoms, though it can lead to cirrhosis (severe liver scarring), liver cancer and even liver failure. Certain factors 鈥?such as type 2 diabetes, being overweight or having family members with the disease 鈥?can increase the risk of developing NASH, for which there are currently no FDA-approved therapies.Want more breaking news?Subscribe to Technology Networks鈥?daily newsletter, delivering breaking science news straight to your inbox every day.Subscribe for FREE The Revenant star Leonardo DiCaprio seems to be in demand by Warner Brothers as they reportedly want to sign him on for the forthcoming Joker movie.Angels or Demons? How clown and joker emerge as a symbol of our timesThe entertainment company has an eye on him and believes that he will best portray the role聽in the untitled movie centred on the origins of ugg hausschuhe the most iconic Batman villain. They seem to be聽going high and low to convince the Oscar- adidas campus noir winner to get on board.No offer has been made to the Great Gatsby star so far as director Martin Scorsese鈥檚 production contract has not yet been finalised. However, it won鈥檛 come as a surprise if Scorsese jumps at the opportunity to take DiCaprio as soon as it is finalised, as the pair are frequent collaborators.Did you know? : Jared Leto鈥檚 Oscar is a filthy messThey have previously joined hands for The Aviator, Gangs of New York, The Departed, Shutter Island and The Wolf of Wall Street.The Joker was originally played adidas campus 00's by Mr Nobody actor Jared Leto

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Keqr Obama offers help to eliminate terrorism from Pakistan
Calando Pharmaceuticals has announced that pre-clinical development of a second siRNA oncology therapeutic, CALAA-02, is underway. The intracellular target for CALAA-02 is HIF-2alpha, or Hypoxia Inducible Factor-2 a asics gel kayano lpha.HIF-2alpha is overexpressed in a number of solid tumors and is critical for many aspects of tumorigenesis, such as metastasis, angiogenesis, tumor cell proliferation, and tu yeezy mor response to radiation. HIF-2alpha has been difficult to target using traditional drugs but is effectively targeted by the proprietary siRNA in CALAA-02."We are encouraged by the results obtained thus far with our proprietary anti-HIF-2alpha siRNA and are excited to pursue pre-clinical development of CALAA-02," said Calando CSO for siRNA delivery, Jeremy Heidel, Ph.D. "We expect our experience with converse all star CALAA-01 will simplify and accelerate CALAA-02 development."Calando's first siRNA therapeutic, CALAA-01, which targets the M2 subunit of ribonucleotide reductase, is currently in a Phase I clinical tria RAWALPINDI/ISLAMABAD:The Lahore High Court (LHC) on Tuesday directed interior secretary to de adidas samba hombre cide the applica nb 574 tion of widow of a customs inspector, who has requesting putting name of model Ayyan Ali on the exit control list (ECL), within 10 days.Justice Atir Mahmood of the LHC Rawalpindi bench disposed of the petition filed by Saima Ejaz, widow of Inspector Ejaz Mahmood, and Riaz Afzal, brother of the deceased.Citing secretary interior, Federal Investigation Officer director gene adidas samba vegan ral, Rawalpindi regional police officer and city police officer, and Ali as respondents, the petitioners had maintained that the model needed to be stopped from proceeding to foreign countries.The petitioners said that Ali鈥檚 name must be put on the ECL as she was responsible for murder of Inspector Mahmood, who was an important prosecution witness in the currency-smuggling case against the model.The widow had claimed that her husband had told her that unidentified people were pressurising him to help Ali in the

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Swbr Injecting New Life into Old Antibiotics
Mr. Watson will also support business development activities and report directly to RainDance President and CEO, Roopom Banerjee. 鈥淩ainDance is at an exciting inflection point in its commercial evolution, and its products are well on their way to becoming enduring medical research solutions that will further advance the performance levels and economics necessary to realiz dunk low e the promise of genomics鈥滿r. Watson has more than 20 years of experience in developing and commercializing innovative genomics technologies. He joins RainDance from Life Technologies where he was most recently Vice President, SOLiD Sequencing Product Management. In this role, Mr. Watson was responsible for business strategy, marketing and product management for all SOLiD sequencing, as we nike dunk uomo ll as single-molecule DNA sequencing systems and applications. Previously, he led Applied Biosystems鈥?(now part of Life Technologies) capillary electrophoresis (CE) sequencing business, including instruments, reagents, an yeezys schuhe d software. M DERA GHAZI KHAN:In a unique protest of its kind, doctors took to the streets against the government鈥檚 induction policy by riding donkey carts in Dera Ghazi Khan.As part of the protest, the doctors boycotted the out-patient department and closed the emergency ward of Teaching Hospital, Dera Ghazi Khan on Monday. On the occasion, they shouted slogans against the government and demanded addressal of their grievances.While speaking to The Express Tribune, Young Doctors Association (YDA) Vice-President D newbalance 574 r Anjum Baloch and others said the doctors had been protesting newbalance 530 against the central induction policy of the government but the authorities failed to address their demands. They demanded of the government to revise the induction policy.聽 The doctors also announced complete boycott of medical facilities across Punjab from December 7, if their grievances were not fulfilled.Meanwhile, YDA Acting President Dr Ateeq told The Express Tribune that the provincial government had transferr adidas schuhe campus ed Dr Anjum Ba

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Eprr A Shield for a Sheath
Although epigenetic disorders 鈥?diseases caused by faulty gene expression 鈥?are still rare overall, babies born using fertility t asics reatments have up to an 11-fold higher risk of inheriting them. According to a new mouse study from the Magee-Womens Research Institute (MWRI), the problem likely lies with the technology, not the mother鈥檚 age.The study found that fertility treatments caused epigenetic changes associated with Beckwith-Wiedemann, Silver-Russell and Angelman syndromes in mouse embryos. Surprisingly, maternal age itself had no such effect. 鈥淲omen of advanced maternal age might have one less thing to worry about,鈥?said lead author Aud nb rey Kindsfather, a medical stude nike dunks high nt researcher at MWRI. 鈥淲e need clinical studies to back that up, but this is a promising animal model that clinical studies could be based on.鈥?Women are increasingly delaying childbirth, and as a woman ages, so does her reproductive system. The odds of conception go down, while the odds of genetic disorders, such as PESHAWAR:A person who is transgender was tortured during a marriage ceremony in Cantt on Saturday.According to the police, Sunny went to perform at Defence Marriage Hall. While she was at the hall, an armed man, identified as Bombar Khan, reached the site and brutally tortured her. He also tried to kidnap her. However, she screamed therefore others, who were present at the hall, managed to protect her.A rights activist, Qamar Naseem, told The Express Tribune Bombar has been a 鈥減ermanent nuisance鈥?for the transgender community in the city.鈥淪unny is terrified,鈥?he said. 鈥淪he does not want to go to the police station and register an FIR against him as previously those who went to the police station were fined by [ adidas samba uomo Bombar].鈥濃€淵ou will see [Bombar] armed with multiple AK-4 adidas samba verte 7s at a time as he carries two in both hands and one hangs from his shoulder,鈥?Naseem added. 鈥淗e is a nightmare nb 550 for these poor people.鈥滱ccording to Naseem, the transgender community is really disappointed as those who attack

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Bgcj Pesticide-polluted Water Decontaminated With Innovative Nanomaterial
A group of researchers from the Area of Toxicology in the Department of Nutrition and Bromatology. Toxicology and Legal Medicine at the University of Seville have published a globally pioneering study that shows that steaming freshwater fish for more than two minutes reduces the presence of cylindrospermopsin, a cyanotoxin, by up to 26%. However, if boiled, the reduction is smaller, 18%, with the corresponding increase in risk for nike jordan damen the consumer. Another important conclusion from their research was that these biotoxins, which are harmful to the body, pass into the water that has been used for cooking.This study, which has been published in Food Control,centres on a species of freshwater fish, tilapia and specifically, the cyanotoxin analysed was cylindrospermopsin.鈥淐yanotoxins are produced by a g yeezy 700 roup of bacteria called cyanobacteria, which are converse schuhen mainly found in freshwater. They are emerging toxins, which currently need to be tested to evaluate the risks that their presence in water and foo KARACHI:All the information you need on Karachi will be just one click away as NGO Shehri launched on Friday a project to compile ugg everything you need to know about local governance.NGO Shehri - Citizens for a Better Environment has joined hands with USAID Small Gra stanleycup nts and Ambassador's Fund Programme for 'Empowered Citizens for Improved Urban Governance' project that aims to put together a comprehensive portal to ensure proactive and informed engagement of the people of Karachi.By developing a handbook on the Sindh Local Government Ordinance (SLGO), a web portal, eco map and mobile applications, the project will improve coordination between different government departments and the residents.According to urban planner Farhan Anwar, w uggs hausschuhe ho is also the project manager, a similar project has also been implemented in India and was quite successful.Nation's first cyber harassment helpline to be launched soonSpeaking at the launch, local government secretary Muhammad Ramzan Awan said that the pro

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Broa Neglected Karachi suffers in rain aftermath: MQM
Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with l yeezys iver cancer. This discovery provides a potentially new therapeutic approach to treating o new balance 327 ne of the leading causes of cancer-related death worldwide.A cancer translational research team consisting of physicians, and basic scientists created an integrative therapy that combined minimally invasive radiofrequency ablation (RFA) with the chemotherapy drug sunitinib. Individually, each treatment has a modest effect in the treatment of liver cancer. The team hypothesized that pairing the two treatments would have a profound effect by activating an immune response to target and destroy liver cancer cells. That's exactly what their research revealed."We treated tumor-bearing mice with sunitinib to suppress the cancer cells' ability asics to evade detection by the immune system, then the RFA acted as a spark that ignited Minister of State for Capital Administration and Development Division (CADD) Ta adidas sambarose riq Fazal Chaudhry has directed the officials of the Prime Minister stanley shop Education Reform Programme to prepare performance-based appraisal system to evalua new balance bleu te performance of teachers and heads of educational institutes.The state minister said this while chairing a meeting to review the progress of projects on the schedule on Wednesday.He said that the prime minister had tasked him to improve the education and heath sectors of the capital according to international standards.鈥淭hese measures will improve the service delivery and quality of education in the education sector,鈥?Chaudhary continued.Key Performance Indicators will be prepared for the appraisal system to assess the performance on scientific lines using best practices prevalent in the world.The reform team will coordinate with the Punjab Information Technology Board (PITB) to seek technical assistance in preparing IT-based systems and training of staff. He

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Fczd DSMB Supports Continuation of the Phase III Clinical Trial of Iluvien for the Treatment of DME
The American Society of Clinical Oncology nike dunkpanda (ASCO) today issued a clinical practice guideline on human papillomavirus converse schuhe (HPV) vaccination for the prevention of cervical cancer. This is the first guideline on primary prevention of cervical cancer that is tailored to multiple regions of the world with different levels of socio-economic and structural resource settings, offering evidence-based guidance to health care providers worldwide.The guideline includes specific recommendations according to four levels of resource settings: basic, limited, enhanced and maximal. The levels pertain to financial resources of a country or region, as well as the dev yeezys elopment of its health system - including personnel, infrastructure and access to services. The guideline complements ASCO's two other global, resource-stratified guidelines on cervical cancer, also stratified to these four levels of resources.Key guideline recommendations:鈥?In all environments and independent of the resource settings, two doses o ISLAMABAD:Chinese inv stanley products estors see huge investment opportunities in Pakistan in a variety of sectors and are optimistic about collaborating with local businessmen.This was said by Kashgar Economic Information Bureau Director General Huang Li Dong, while leading a delegation of the Kashgar Chamber of Commerce and Industry, Chi ugg na on a visit to the Islamabad Chamber of Commerce and Industry (ICCI) to explore opportunities of business collaboration.The delegation represented various sectors including automobile, steel, industrial mach ugg boots f眉r damen inery and agriculture development.Huang said the purpose of their visit was to explore Pakistan's market and after visiting Karachi, Lahore and Islamabad they found a lot of investment opportunities.He emphasised the importance of regular interaction between private sectors of both countries in order to exploit all untapped areas for mutual cooperation."The Silk Road is a historic trade route that China has now revived by undertaking infrastructure projects under

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Qvzy Behind the scenes Experiencing the creative process with Ali Khan
The active agents of many drugs are natural products, so called because often only microorganisms are able to produce the complex structures. Similar to the production line in a factory, large enzyme com dunk low plexes put these active agent molecules together. A team of the Technical University of Munich (TUM) and the Goethe University Frankfurt has now succeeded in investigating the basic mechanisms of one of these molecular factories.Many important drugs such as antibiotics or active agents against cancer are natural baskets yeezy products which are built up by microorganisms for example bacteria or fungi. In the laboratory, the air force 1 herren se natural products can often be not produced at all or only with great effort. The starting point of a large number of such compounds are polyketides, which are carbon chains where every second atom has a double bound to an oxygen atom.In a microbial cell such as in the Photorhabdus luminescens bacterium, they are produced with the help of polyketide synthases (PKS). In order to b KARACHI:Heatwaves, droughts in Thar and floods in Chitral are some of the adverse effects of climate change, pointed out Aamir Amjad of the Friedrich Nauman Foundation (FNF).He was speaking at a day-long workshop held at Council of Pakistan Newspaper Editors (CPNE) office on Thursday. The event was organised by ugg boots f眉r damen FNF, Sustainable Initiatives and CPNE to create awareness about the pr ugg boots tasmania essing issue of climate change and capacity building of journalists.The workshop participants were briefed by Sustainable Initiatives executive-director Farhan Anwar and sustainability consultant Nazish Shekha. The two experts engaged the participants to help them expand their knowledge base in order to perform bett adidas campus 00's er professionally.The workshop spanned various sessions and activities and encouraged discussions among the participants on the topic of climate change and the role they could play as journalists.Anwar traced the history of sustainable development and the rise of the issue of climate change. Definin

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Bcyj Operation 021 is back in theatres and Jami cannot believe his luck
During routine navigation in daily life, our brains use spatial mapping and memory to guide us from point A to point B. Just as routine: making a mistake in navigation that requires a course correction.Now, researchers at Harvard Medical School have identified a specif new balance 550 ic group of neurons in a brain region involved in navigation that undergo bursts of activity when mice running a maze veer off course and correct their error.The findings,publishe nike af1 d July 19 inNature, bring scientists a step closer to understanding how navigation works, while raising new questions. These questions include the specific role these neurons play during navigation, an yeezy 700 d what they are doing in other brain regions where they are found.Want more breaking news?Subscribe to Technology Networks鈥?daily newsletter, delivering breaking science news straight to your inbox every day.Subscribe for FREE Sweden footballer Zlatan Ibrahimovic has confirmed he will sign for Manchester United after leaving Paris St-Germain."Time to let the world know. My next destination is Manchester United," he tweeted.Time to let the world know. My next destination is @ManUtd pic.twitter.com/DAK7iYlrCq— Zlatan Ibrahimovi膰 (@Ibra_official) June 30, 2016Ibrahimovic to quit international du adidas original campus ty after Euro 2016The 34-year-old striker will link up again with his former Inter Milan boss adidas samba Jose Mourinho at Old Trafford.United, who finished fifth in the Premier League last season and failed to qualify for the Champion adidas campus pink s League, have yet to confirm the move.

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Iyet Govt asks provinces to allot land for 46 new hospitals
It鈥檚 no secret that going without sleep can affect people鈥檚 mood, but a new study shows it does not interfere with their ability to evaluate emotional situations.It is often assumed that feeling more negative will color people鈥檚 experience of emotiona nike dunks l images and events in the environment around them. However, Washington State University researchers found that while going 24 hours without sleep impacted study participants鈥?mood, it did not change their performance on tests evaluating their ability to process emotional words and images.鈥淧eople do become less happy through sleep deprivation, but it鈥檚 not affecting how they are processing emotional stimuli in their environment,鈥?said Anthony Stenson, a WSU psychology doctoral student and lead author of the study in Plos One.The findings have implicatio yeezy 350 ns for healthcare providers, law enforcement and people in other long-hour professions who need to be able to control their own emotions during stressful and emot asics gel kayano ionally trying situations. S Tesla said Thursday a driver, identified as Joshua Brown, was killed while using its "autopilot" self-driving mechanism on its Model S electric car, leading to a federal s ugg boots f眉r damen afety investigation.Tesla said the National Highway Traffic Safety Administration (NHTSA) had opened a "preliminary evaluation" into the performance of Autopilot after the electric car company notified the agency of the fatality.In a statement, Tesla said the fatality was "a tragic loss" and was the fi adidas samba plataforma rst such incident with its Autopilot system activated. The interior of a Tesla Model S is shown in autopilot mode in San Francisco, California, US, April 7, 201 nb 6. PHOTO: REUTERS